Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth - 20/08/11
Abstract |
Objective |
Variants in the folate metabolism pathway affect the accumulation of homocysteine are modified by nutrient levels and have been linked to adverse birth outcomes.
Study design |
We examined the relationship among MTHFR(677), MTHFR(1298), MTR(2756), MTRR(66), and SHMT1(1420), dietary folate intake, and preterm and small-for-gestational-age (SGA) birth in a nested case-control study of black and white women.
Results |
White carriers of SHMT1(1420)T or MTRR(66)A had an increased risk of spontaneous preterm birth (odds ratio [OR] = 1.9, 95% CI 1.1-3.1; OR = 2.0, 95% CI 1.1-3.6 respectively). In black women, there appeared to be an interaction between dietary folate intake and the SHMT1(1420)T variant allele, such that only carriers who also were in the lowest quartile of dietary folate intake had higher risk of spontaneous preterm birth (OR = 2.6, 95% CI 0.8-8.0) and SGA (OR = 2.9, 95% CI 0.9-8.9).
Conclusion |
Our results suggest the possibility of a direct or indirect role for the SHMT1(1420)T variant in spontaneous preterm or SGA births.
Le texte complet de cet article est disponible en PDF.Key words : Preterm birth, Small for gestational age, Intrauterine growth, MTHFR, Polymorphism, SHMT1, MTRR, MTR
Plan
| Financial support for this research provided in part by a pilot projects grant from the UNC Center for Environmental Health and Susceptibility (National Institute of Environmental Health Sciences, P30ES10126), the National Institute of Child Health and Human Development (HD28684, HD28684A), the General Clinical Research Centers program of the Division of Research Resources (RR00046), National Institutes of Health, and the National Institute of Environmental Health Sciences and Environmental Protection Agency Children’s Environmental Health Center (P01ES09584). Reprints not available from the authors. |
Vol 195 - N° 5
P. 1231.e1-1231.e11 - novembre 2006 Retour au numéro
Article précédent
- Nasal bone assessment in prenatal screening for trisomy 21
- J.D. Sonek, S. Cicero, R. Neiger, K.H. Nicolaides
- Analysis of association between maternal tumor necrosis factor-⍺ promoter polymorphism (–308), tumor necrosis factor concentration, and preterm birth
- Ramkumar Menon, Mario Merialdi, Ana P. Betrán, Siobhan Dolan, Lan Jiang, Stephen J. Fortunato, Scott Williams
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?