MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia - 20/08/11
Reprint requests: Dr Cynthia Standley, Professor of Physiology, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308.Abstract |
Objective |
We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis.
Study design |
Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipumps were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer.
Results |
Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal.
Conclusion |
Cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia.
Le texte complet de cet article est disponible en PDF.Key words : Preeclampsia, Hypertension, Heart, Magnesium, Rats
Plan
| Funded, in part, through a grant provided by the National Heart, Lung and Blood Institute to C. Standley (1 R15 HL073777-01). |
Vol 195 - N° 5
P. 1398-1403 - novembre 2006 Retour au numéro
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