Association Between Alcohol Consumption and Both Osteoporotic Fracture and Bone Density - 20/08/11
, Hillary V. Kunins, MD, MS, MPH a, c, Jeffrey L. Jackson, MD, MPH d, Shadi Nahvi, MD a, c, Amina Chaudhry, MD, MPH e, Kenneth A. Harris, MD, PhD a, c, Rubina Malik, MD, MS a, Julia H. Arnsten, MD, MPH a, b, c
Requests for reprints should be addressed to Karina M. Berg, MD, MS, Montefiore Medical Center, Division of General Internal Medicine, 111 East 210th Street, Bronx, NY 10467.Abstract |
Objective |
Alcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and meta-analysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling.
Methods |
MEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force.
Results |
We pooled effect sizes for 2 specific outcomes (hip fracture and bone density) and synthesized data qualitatively for 4 outcomes (non-hip fracture, bone density loss over time, bone response to estrogen replacement, and bone remodeling). Compared with abstainers, persons consuming from more than 0.5 to 1.0 drinks per day had lower hip fracture risk (relative risk=0.80 [95% confidence interval, 0.71-0.91]), and persons consuming more than 2 drinks per day had higher risk (relative risk=1.39 [95% confidence interval, 1.08-1.79]). A linear relationship existed between femoral neck bone density and alcohol consumption. Because studies often combined moderate and heavier drinkers in a single category, we could not assess relative associations between alcohol consumption and bone density in moderate compared with heavy drinkers.
Conclusion |
Compared with abstainers and heavier drinkers, persons who consume 0.5 to 1.0 drink per day have a lower risk of hip fracture. Although available evidence suggests a favorable effect of alcohol consumption on bone density, a precise range of beneficial alcohol consumption cannot be determined.
Le texte complet de cet article est disponible en PDF.Keywords : Alcohol, Bone mineral density, Hip fracture, Meta-analysis, Osteoporosis
Plan
| This study was funded by the Program of Research Integrating Substance Use in Mainstream Healthcare with support from the Robert Wood Johnson Foundation, National Institute on Drug Abuse (NIDA), and National Institute on Alcohol Abuse and Alcoholism (co-directors A. T. McLellan, PhD, and B. J. Turner, MD, MSEd). Additional support was provided by grants K23 DA021087 from the NIDA and the National Institute of Mental Health and a Robert Wood Johnson Foundation Physician Faculty Scholar Award to Dr Berg; grants R25 DA14551 and R01 DA015302 from the NIDA to Dr Arnsten; and a Center for AIDS Research grant (P30 AI51519) to the Albert Einstein College of Medicine of Yeshiva University from the National Institutes of Health. |
Vol 121 - N° 5
P. 406-418 - mai 2008 Retour au numéro
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