Occurrence and Risk Factors for Autoimmune Thyroid Disease in Patients with Atrophic Body Gastritis - 20/08/11
Requests for reprints should be addressed to Bruno Annibale, MD, Department of Digestive and Liver Disease, University “La Sapienza,” Ospedale Sant’Andrea, Via di Grottarossa 1035, Roma 00189, Italy.Abstract |
Purpose |
To investigate the occurrence of and risk factors for autoimmune thyroid disease in atrophic body gastritis patients.
Methods |
Cross-sectional study on 401 consecutive outpatients with atrophic body gastritis. Diagnostic work-up of thyroid disease was completed in 319 atrophic body gastritis patients (225 women, median age 55.5 years [range 17-95 years]). Data on anagraphics, lifestyle, family history, and biochemical and histological items were obtained at baseline, and associations between atrophic body gastritis and autoimmune and nonautoimmune thyroid diseases were explored through descriptive statistics and logistic regression analyses.
Results |
Of the 319 atrophic body gastritis patients, 169 (53%) had an associated thyroid disorder, and 89 (52.7%) of these were unaware of it. The thyroid disease was autoimmune in 128 patients (75.7%) and nonautoimmune in 41 patients. Logistic regression showed that risk factors for having autoimmune thyroid disease in atrophic body gastritis patients were female sex (odds ratio [OR] 5.6, 95% confidence interval [CI], 2.6-12.1), presence of parietal cell antibodies (OR 2.5, 95% CI, 1.1-5.5), and presence of metaplastic atrophy (OR 2.2, 95% CI, 1.0-5.0).
Conclusions |
Autoimmune thyroid disease and atrophic body gastritis occur in a closely linked fashion, suggesting that atrophic body gastritis patients should be investigated for an occult autoimmune thyroid disease, in particular women and those with positive parietal cell antibodies.
Le texte complet de cet article est disponible en PDF.Keywords : Atrophic body gastritis, Autoimmune thyroid disease, Intrinsic factor antibodies, Parietal cell antibodies, Pernicious anemia
Plan
| This study was funded by grants from the Italian Ministry for University and Research PRIN 2005. |
Vol 121 - N° 2
P. 136-141 - février 2008 Retour au numéro
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