A Prospective Randomized Study to Determine the Efficacy of Preoperative Topical Levofloxacin in Reducing Conjunctival Bacterial Flora - 21/08/11
, Israel Aguirre-Romo a, Christopher N. Ta b, Julia Dudichum a, Markus Bayrhof a, Volker Klauss a, Anselm Kampik a
Inquiries to Thomas C. Kreutzer, Department of Ophthalmology, University of Munich (LMU), Mathidelstr. 8, 80336 Munich, GermanyRésumé |
Purpose |
To compare the efficacy of topical levofloxacin in combination with povidone–iodine irrigation vs povidone–iodine (PVI) alone in reducing conjunctival bacteria.
Design |
Prospective, randomized, controlled trial.
Methods |
One hundred and forty eyes of 140 patients scheduled to undergo intraocular surgery eyes were randomized to either group 1 or 2 (70 each). Whereas group 1 eyes had no prophylactic antibiotic, eyes in group 2 received topical treatment with one drop of 0.5% levofloxacin four times on the day before surgery. Both groups underwent irrigation of the fornices with 1% PVI. Conjunctival swabs were inoculated on solid and broth culture media to determine bacterial growth.
Results |
Of 132 eyes evaluated, baseline culture analysis in thioglycolate demonstrated positive culture results in 55 (84.6%) of 65 eyes from group 1, similar to 55 (82.1%) of 67 eyes in group 2 (P = .697). Before surgery, 57 (87.7%) of 65 eyes in group 1 had positive culture results, compared with 50 (74.6%) of 67 eyes in group 2 (P = .055). After irrigation with PVI, 20 (30.8 %) of 65 eyes in group 1 had positive culture results, compared with only eight (11.9%) of 67 eyes in group 2 (P = .008). After surgery, 15 (23.1%) of 65 eyes in group 1 and six (9.0%) of 67 eyes in group 2 had positive culture results (P = .027).
Conclusions |
Our study shows an enhanced effect of using topical levofloxacin in combination with PVI irrigation to reduce conjunctival bacteria in patients undergoing intraocular surgery.
Le texte complet de cet article est disponible en PDF.Plan
Vol 145 - N° 1
P. 136 - janvier 2008 Retour au numéro
Article précédent
- Comparison of Polyhexamethylene Biguanide and Chlorhexidine as Monotherapy Agents in the Treatment of Acanthamoeba Keratitis
- Natasha Lim, David Goh, Catey Bunce, Wen Xing, Graham Fraenkel, Tom R.G. Poole, Linda Ficker
- Prevalence and Associations of Asymptomatic Retinal Emboli in Latinos: The Los Angeles Latino Eye Study (LALES)
- Susan Liu Hoki, Rohit Varma, Mei Ying Lai, Stanley P. Azen, Ronald Klein, Los Angeles Latino Eye Study Group
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?