Hemodynamic Mechanisms Underlying the Incomplete Tolerance to Caffeine's Pressor Effects - 21/08/11
Doi : 10.1016/j.amjcard.2005.01.093
Noha H. Farag, MD a, ⁎ 
, Andrea S. Vincent, PhD a, b, Barbara S. McKey, RN b, Thomas L. Whitsett, MD c, William R. Lovallo, PhD a, b
, Andrea S. Vincent, PhD a, b, Barbara S. McKey, RN b, Thomas L. Whitsett, MD c, William R. Lovallo, PhD a, b a Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
b Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
c Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Dr. Farag's address is Veterans Affairs Medical Center (151A), 921 NE 13th Street, Oklahoma City, Oklahoma 73104Résumé |
Blood pressure (BP) and cardiovascular hemodynamics were assessed at baseline and after caffeine administration in a 4-week, placebo-controlled, double-blind, randomized, crossover trial of caffeine tolerance formation. Half of the subjects developed tolerance to the pressor effect of caffeine, whereas the other half continued to show increases in BP after caffeine ingestion (F = 16.7, p <0.0001). In the subjects who did not develop tolerance, peripheral resistance increased incrementally as the daily dose of caffeine increased (F = 2.8, p = 0.05).
Le texte complet de cet article est disponible en PDF.| This work was supported by Grant HL32050 from National Heart, Lung, and Blood Institute and Grant M01-RR14467 from the National Center for Research Resources and the National Institutes of Health, Bethesda, Maryland. |
© 2005
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Vol 95 - N° 11
P. 1389-1392 - juin 2005 Retour au numéro
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