Racial differences in outcome and treatment effect in congestive heart failure - 21/08/11

Doi : 10.1016/j.ahj.2005.03.060

James Mathew, MD, FACC, FACP ^a,^b,^⁎ , Janet Wittes, PhD ^c, Frances McSherry, MS ^d,^e, William Williford, PhD ^d,^e, Rekha Garg, MD ^f, Jeffrey Probstfield, MD, FACC, Salim Yusuf, MD, FRCP, DPhil ^g,^h
Digitalis Investigation Group
^a Wisconsin Cardiovascular Group, Milwaukee, Wisc
^b University of Iowa College of Medicine, Iowa City, Iowa
^c Statistics Collaborative, Washington, DC
^d Cooperative Studies Program, VA Medical Center, Perry Point, Md
^e Department of Epidemiology and Preventative Medicine, University of Maryland School of Medicine, Md
^f National Heart, Lung, and Blood Institute, Bethesda, Md
^g Department of Medicine and Epidemiology, University of Washington, Seattle, Wash
^h Division of Cardiology, McMaster University, Hamilton, Ontario, Canada

^⁎Reprint requests: James Mathew, MD, FACC, FACP, Wisconsin Cardiovascular Group, 2315 N Lake Drive # 613, Milwaukee, WI 53215.

Résumé

Background

In congestive heart failure (CHF), it is unknown whether race affects mortality and whether the effect of treatments differs by race.

Methods

This study was a post hoc analysis of data from the DIG study that evaluated the effect of digoxin on morbidity and mortality in CHF.

Results

Investigators followed 897 black and 6660 white participants for a mean of 37 months. Compared with whites, blacks were younger (60 ± 13 vs 65 ± 11 years). Total mortality was 34.2% in blacks and 33.6% in whites; hospitalization for worsening CHF occurred in 39% of blacks and 28% of whites. Cox regressions with race as the only covariate showed no effect of race on risk for death (relative risk = 1.04, 95% CI 0.93-1.18, P = .49) but an increase in CHF hospitalization in blacks (relative risk = 1.52, 95% CI 1.35-1.70, P = .0001). Multivariate Cox regression showed no difference by race in risk for death or death/hospitalization for CHF and no difference in the effect of digoxin on either end point.

Conclusion

Race is not an independent predictor of mortality in CHF. The effect of digoxin on morbidity and mortality in CHF does not differ in blacks and whites.

Le texte complet de cet article est disponible en PDF.

Plan

Export

Vol 150 - N° 5

P. 968-976 - novembre 2005 Retour au numéro

Article précédent

Depression predicts mortality and hospitalization in patients with myocardial infarction complicated by heart failure
John S. Rumsfeld, Philip G. Jones, Mary A. Whooley, Mark D. Sullivan, Bertram Pitt, William S. Weintraub, John A. Spertus

| Article suivant

Diastolic dysfunction after mediastinal irradiation
Paul A. Heidenreich, Steven L. Hancock, Randall H. Vagelos, Byron K. Lee, Ingela Schnittger

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Racial differences in outcome and treatment effect in congestive heart failure - 21/08/11

Résumé

Background

Methods

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL