Vitamin D: Metabolism - 21/08/11
, Dare V. Ajibade, BA a, Puneet Dhawan, PhD a, Adam J. Fechner, MD b, Leila J. Mady, BA a
Corresponding author.Résumé |
The biologically active metabolite of vitamin D, 1,25(OH)2D3, affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH)2D3. The role of extrarenal 1⍺(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.
Le texte complet de cet article est disponible en PDF.Keywords : Vitamin D metabolites, Vitamin D hydroxylases, Vitamin D binding protein, FGF23, Kidney, Placenta
Plan
| Studies referenced from the laboratory of S.C. were supported in part by NIH grant DK-38961-21. |
Vol 39 - N° 2
P. 243-253 - juin 2010 Retour au numéro
Article précédent
- Preface
- Sol Epstein
- The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3
- J. Wesley Pike, Mark B. Meyer
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?