Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication - 21/08/11
Abstract |
Objective |
To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
Study design |
We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
Results |
Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m2 to 95 ± 21 mL/minute/1.73m2 (P <.0001). SKGFR of the duplex side similarly increased from 26 ± 7.7 mL/minute/1.73m2 to 38 ± 12.6 mL/minute/1.73m2 (P <.0001). In terms of split function, the affected kidney had a remarkable stable function between the two measurements, 40% ± 8.6 and 39% ± 8.3 (P=.94), respectively. However, cases with the lowest initial split function (<30%) had the lowest initial SKGFR and the worst further evolution.
Conclusion |
In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stable during follow-up.
Le texte complet de cet article est disponible en PDF.Mots-clés : Cr-51 EDTA, 99mTc-DTPA, GFR, 99mTc-MAG3, SKGFR, US, UTI, VCUG, VUR
Plan
Supported by a grant from The Belgian Kids' Foundation (to Dr K. Ismaili). The present results were partly presented at the joint meeting of the Société de Néphrologie Pédiatrique (SNP) and the Arbeitsgemeinschaft Pädiatrische Nephrologie (APN), May 15-17, 2003, Strasbourg, France. |
Vol 147 - N° 2
P. 208-212 - août 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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