Transient Bulging Fontanelle after Vaccination: Case Report and Review of the Vaccine Adverse Event Reporting System - 21/08/11
, Amy Weiss, MD, Robert Ball, MD, MPH
Reprint requests: Robert P. Wise, MD, MPH, FDA CBER HFM-225, 1401 Rockville Pike, Rockville, MD 20852-1448.Abstract |
Objective |
To describe the features of transient bulging fontanelle (TBF) after vaccination.
Study design |
We searched the Vaccine Adverse Event Reporting System database for reports describing bulging fontanelle. We defined a definite TBF case as a patient with a bulging fontanelle, normal neuroimaging and cerebrospinal fluid analysis, and absence of a depressed level of consciousness, focal neurologic findings, or identified cause. Follow-up had to reveal normal development. Probable cases lacked either lumbar puncture or neuroimaging or both but met all other criteria.
Results |
We identified 18 patients with definite or probable TBF. The median age at presentation was 4.5 months, interval from vaccination to symptom onset was 18 hours, and time to resolution was 3 days. Fifteen children were febrile.
Conclusions |
We cannot conclude that vaccines cause TBF. Further controlled studies are necessary. Even if further research verifies TBF as a rare side effect, immunization benefits would still vastly outweigh this hypothetical risk. However, confirmation of a vaccine association could modify the management of infants who develop TBF after immunizations.
Le texte complet de cet article est disponible en PDF.Mots-clés : COSTART, DT, DTP, DTaP, HIB, PCV, TBF, VAERS
Plan
Vol 147 - N° 5
P. 640-644 - novembre 2005 Retour au numéro
Article précédent
- Renal glycosuria: Occurrence in two siblings and a review of the literature
- Aaron Friedman
- Clinical Impact of Corticosteroid-Induced Adrenal Suppression during Treatment for Acute Lymphoblastic Leukemia in Children: A Prospective Observational Study Using the Low-Dose Adrenocorticotropin Test
- Mariane Rix, Niels Holtum Birkebæk, Steen Rosthøj, Niels Clausen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?