A Randomized Controlled Trial of Fluid Supplementation in Term Neonates With Severe Hyperbilirubinemia - 21/08/11
, Anil Narang, MD
Reprint requests: Dr. Praveen Kumar, Department of Pediatrics, PGIMER, Chandigarh 160012, India.Abstract |
Objective |
To evaluate the effectiveness of fluid supplementation in decreasing the rate of exchange transfusion and the duration of phototherapy in term neonates with severe nonhemolytic hyperbilirubinemia.
Study design |
This was a randomized controlled trial conducted in a tertiary care referral unit in northern India. Seventy-four term neonates with severe nonhemolytic hyperbilirubinemia (total serum bilirubin > 18 mg/dL [308 μmol/L] to < 25 mg/dL [427 μmol/L]). The subjects were randomized to an “extra fluids” group (intravenous fluid supplementation for 8 hours and oral supplementation for the duration of phototherapy; n = 37) or a control group (n = 37).
Results |
At inclusion, 54 infants (73%) had high serum osmolality, including 28 (75%) in the extra fluids group and 26 (70%) in the control group. The proportion of infants who underwent exchange transfusion was lower in the extra fluids group than in the control group: 6 (16%) versus 20 (54%)(P = .001; relative risk = 0.30; 95% confidence interval = 0.14 to 0.66). The duration of phototherapy was also shorter in the extra fluids group: 52 ± 18 hours versus 73 ± 31 hours (P = .004).
Conclusion |
Fluid supplementation in term neonates presenting with severe hyperbilirubinemia decreased the rate of exchange transfusion and duration of phototherapy.
Le texte complet de cet article est disponible en PDF.Mots-clés : AAP, ANOVA, IV, TSB
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Vol 147 - N° 6
P. 781-785 - décembre 2005 Retour au numéro
Article précédent
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