Clomipramine-induced hypersensitivity syndrome with unusual clinical features - 21/08/11
Doi : 10.1016/j.jaad.2005.03.003
Youichi Nishimura, MD, PhD ⁎ 
, Akihiko Kitoh, MD, Yoko Yoshida, MD, PhD, Toshihiro Tanaka, MD, PhD
, Akihiko Kitoh, MD, Yoko Yoshida, MD, PhD, Toshihiro Tanaka, MD, PhD From the Department of Dermatology, Tenri Yorozu Hospital
Correspondence to: Youichi Nishimura, MD, PhD, 200 Mishima, Tenri, Nara 632-8552, Japan.Nara, Japan
Abstract |
Drug-induced hypersensitivity syndrome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus-6 (HHV-6) reactivation. We present a case of clomipramine-induced hypersensitivity syndrome, which displayed in succession two different reactions akin to those described for Gianotti-Crosti syndrome and infectious mononucleosis. HHV-6 reactivation was confirmed serologically after the latter reaction, suggesting that our case may have represented a biphasic reaction to HHV-6 reactivation.
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| Supported by Stiefel Laboratories. Funding sources: None. Conflicts of interest: None identified. Reprints not available from the authors. |
© 2005
American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 53 - N° 5S
P. S231-S233 - novembre 2005 Retour au numéro
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