An Introduction to MR Imaging-Based Stroke Morphometry - 21/08/11

Doi : 10.1016/j.nic.2005.06.004

Nikos Makris, MD, PhD ^a,^b,^⁎ , Verne S. Caviness, MD, DPhil ^a,^b,^c, David N. Kennedy, PhD ^a,^b,^d
^a Department of Neurology, Harvard Medical School, Charlestown, MA, USA
^b Center for Morphometric Analysis, Massachusetts General Hospital, Charlestown, MA, USA
^c Pediatric Neurology, Massachusetts General Hospital, Charlestown, MA, USA
^d Division of Health Sciences and Technology, Harvard–Massachusetts Institute of Technology, Cambridge, MA, USA

^⁎Corresponding author. Center for Morphometric Analysis, Massachusetts General Hospital, MGH-East Building, 149 13th Street, Charlestown, MA 02129

Résumé

The anatomic description of the stroke lesion is an essential component of clinical diagnosis and treatment and has become an established tool in investigations into underlying stroke pathophysiology. Magnetic resonance (MR) imaging permits quantitative evaluation of the distributed consequences of the pathologic stroke insult. General properties of stroke effects have emerged using these tools. This article surveys the classes of morphometric data that are available from conventional MR images, the methods for extracting quantitative results, and samples of the application of these methods to stroke. These samples highlight anatomic-based considerations regarding the nature of stroke and its repercussions within the brain parenchyma.

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Plan

Methodology

Segmentation

Morphometric descriptors

Implications for cerebral vascular territories

Survey of sample morphometric applications in stroke

Application A: volumetric assessment

Stroke and vascular topography

Stroke volume and brain topography

Application B: Integration of three magnetic resonance modalities

Application C: Integration of magnetic resonance imaging and positron emission tomography

Application D: Alterations in subcortical regions after cortical insult

Related neuroscience themes

Stroke volume and vascular topography

Multimodal imaging

Clinico-anatomic correlations

Structure-function relationships, anatomic connectional map, and “remote effect of disconnection”

Integrated magnetic resonance neuro-examination

Secondary degeneration

Summary

This work was supported by National Institutes of Health Grants PO1 NS27950 and DA 09467, by Human Brain Project Grant NS34189, and by grants from the Fairway Trust and the Giovanni Armenise Harvard Foundation for Advanced Scientific Research.