Betamethasone for lung maturation: testing dose and formulation in fetal sheep - 22/08/11
Résumé |
Objective |
We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep.
Study Design |
Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated.
Results |
The 2 doses of the Beta-PO4 + Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 + Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4.
Conclusion |
Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.
Le texte complet de cet article est disponible en PDF.Key words : corticosteroid, fetal sheep, lung, preterm
Plan
| Supported by National Institutes of Health Grant HL-65397, the National Health and Medical Research Council of Australia, and the Women and Infants Research Foundation of Western Australia. Reprints not available from the authors. |
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| Cite this article as: Jobe AH, Moss TJM, Nitsos I, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. Am J Obstet Gynecol 2007;197:523.e1-523.e6. |
Vol 197 - N° 5
P. 523.e1-523.e6 - novembre 2007 Retour au numéro
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