Second-trimester loss and subsequent pregnancy outcomes: What is the real risk? - 22/08/11
Reprints: Michal A. Elovitz, Center for Research on Reproduction and Women’s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, 1353 Biomedical Research Building II/III, 421 Curie Blvd., Philadelphia, PA 19104Résumé |
Objective |
This study was performed to determine whether second-trimester pregnancy loss was associated with an increased risk for spontaneous preterm birth or recurrent second-trimester loss in a subsequent pregnancy.
Study Design |
A retrospective cohort study was conducted. Patients with a second-trimester pregnancy loss (n = 38), a spontaneous preterm birth (n = 76), and a full term delivery (n = 76) were identified from 2002 to 2005 (index pregnancy). Computerized medical records were used to obtain demographic and obstetrical histories.
Results |
Frequencies of subsequent second-trimester loss were 27%, 3%, and 1% in the second-trimester loss, spontaneous preterm birth, and full-term delivery cohorts, respectively. Frequencies of subsequent spontaneous preterm birth were 33%, 39.5%, and 9% in the same 3 cohorts. Patients with a prior second-trimester loss were 10.8 times more likely to have recurrent second-trimester loss or spontaneous preterm birth, compared with those with prior full-term delivery (confidence interval 3.6 to 32.1, P < .0001).
Conclusion |
Patients with a prior second-trimester loss are at significantly increased risk for spontaneous preterm birth and recurrent second-trimester loss in their next pregnancy.
Le texte complet de cet article est disponible en PDF.Key words : pregnancy outcome, second-trimester pregnancy loss, spontaneous preterm birth, subsequent pregnancy
Plan
| Cite this article as: Edlow AG, Srinivas SK, and Elovitz MA. Second-trimester loss and subsequent pregnancy outcomes: What is the real risk? Am J Obstet Gynecol 2007;197:581.e1-581.e6. |
Vol 197 - N° 6
P. 581.e1-581.e6 - décembre 2007 Retour au numéro
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