Soluble endoglin as a second-trimester marker for preeclampsia - 22/08/11
Résumé |
Objective |
The objective of this investigation was to characterize soluble endoglin (sEng) concentrations in second-trimester serum of women who either develop preeclampsia or have a normal pregnancy.
Study Design |
Single second-trimester serum samples obtained from healthy, nonsmoking women who subsequently developed severe preeclampsia (n = 48) or from healthy nonsmoking women who experienced a normal pregnancy (n = 56) were measured by enzyme-linked immunosorbent assay. Data were reported as mean ± standard deviation.
Results |
Maternal age or gestational age at time of sample was not different between the 2 groups. Patients who later developed preeclampsia delivered earlier, had smaller infants, and had a higher mean arterial pressure than controls. Patients who later developed severe preeclampsia had elevated sEng, compared with those with normal pregnancy (6.19 ± 2.1 vs 5.00 ± 1.0 ng/mL, P = .02).
Conclusion |
Soluble endoglin is elevated in second-trimester maternal serum in patients destined to develop severe preeclampsia.
Le texte complet de cet article est disponible en PDF.Key words : biomarker, preeclampsia, pregnancy, second trimester, soluble endoglin
Plan
| This work was supported in part by Medical University of South Carolina University Research Grant Institutional Review Board Project HR15357. |
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| Reprints not available from the authors. |
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| Cite this article as: Robinson CJ, Johnson DD. Soluble endoglin as a second-trimester marker for preeclampsia. Am J Obstet Gynecol 2007;197:174.e1-174.e5. |
Vol 197 - N° 2
P. 174.e1-174.e5 - août 2007 Retour au numéro
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