Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast - 22/08/11
, Jennifer Flatow Culhane, PhD 2
Reprint requests: Sabina Cauci, PhD, Dipartimento di Scienze e Tecnologie Biomediche, Facoltá di Medicina e Chirurgia, Piazzale Kolbe 4, 33100 Udine, Italy.Résumé |
Objective |
This study was undertaken to examine the influence of coinfections on vaginal innate and adaptive immunity, and microbial enzyme activities of pregnant women with bacterial vaginosis (BV).
Study design |
The population consisted of 265 singleton pregnant women in early gestation (<20 weeks) with BV (Nugent 7-10) who had vaginal fluid collected for measurement of interleukin-1β (IL-1β) and IL-8 concentrations, number of neutrophils, immunoglobulin A against Gardnerella vaginalis (anti-Gvh IgA), and activities of microbial sialidase and prolidase.
Results |
Among women with BV, median levels of vaginal IL-1β (4-fold, P = .005), IL-8 (4-fold, P < .001), and neutrophils (6-fold, P = .013) were greatly increased in women with T vaginalis with respect to women without any coinfection. Yeast increased the level of IL-8 (5-fold, P < .001), but not IL-1β (P = .239) and neutrophils (P = .060). Chlamydia trachomatis and Neisseria gonorrhoeae had no effect on vaginal cytokines. None of the coinfections influenced vaginal anti-Gvh IgA, sialidase and prolidase activities.
Conclusion |
The strong proinflammatory cytokine induction by T vaginalis may contribute to the observed increase in preterm birth among BV positive women coinfected with T vaginalis treated with metronidazole.
Le texte complet de cet article est disponible en PDF.Key words : adverse pregnancy outcome, bacterial vaginosis, interleukin-1β, interleukin-8, prolidase, sialidase, Trichomonas vaginalis, vaginal neutrophils
Plan
| This study was supported by Centers for Disease Control and Prevention/ATPM TS-0626 and TS-0561. Cite this article as: Cauci S, Flatow Culhane J. Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast. Am J Obstet Gynecol 2007;196;133.e1-133.e7. |
Vol 196 - N° 2
P. 133.e1-133.e7 - février 2007 Retour au numéro
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