Retinal Sensitivity Loss and Structural Disturbance in Areas of Capillary Nonperfusion of Eyes with Diabetic Retinopathy - 22/08/11
, Atsushi Sakamoto, Mihori Kita, Daisuke Watanabe, Masanori Hangai, Tetsushi Kimura, Naoaki Kawagoe, Masahumi Ohta, Nagahisa Yoshimura
Inquiries to Kazuaki Nishijima, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Syogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, JapanRésumé |
Purpose |
To assess light sensitivity and morphologic changes of capillary nonperfused areas in diabetic retinopathy.
Design |
Prospective, observational cross-sectional study.
Methods |
Seventeen consecutive patients (20 eyes) with areas of capillary nonperfusion resulting from severe nonproliferative or proliferative diabetic retinopathy were included in the study. All eyes underwent fluorescent angiography and fundus-related microperimetry. Nonperfused areas of the retina were scanned with optical coherence tomography (OCT).
Results |
In all 20 diabetic eyes, areas of capillary nonperfusion detected by fluorescein angiography were associated with the loss of retinal sensitivity. At the edges of the nonperfused area, retinal sensitivity tended to be reduced. The OCT images suggested a structural disturbance of the inner retina and high-reflectivity deposition located between the outer segments of photoreceptor and the retinal pigment epithelium corresponding to the areas of capillary nonperfusion.
Conclusions |
Areas of capillary nonperfusion resulting from severe nonproliferative or proliferative diabetic retinopathy show morphologic changes of the retinal structure, which may lead to a loss of sensitivity.
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Vol 144 - N° 5
P. 755 - novembre 2007 Retour au numéro
Article précédent
- Optical Coherence Tomography Findings in Persistent Diabetic Macular Edema: The Vitreomacular Interface
- Nicola G. Ghazi, Jessica B. Ciralsky, Syed M. Shah, Peter A. Campochiaro, Julia A. Haller
- Anti-Angiogenic Effects of Ribonucleic Acid Interference Targeting Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor-1⍺
- Farzin Forooghian, Bikul Das
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