A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis - 23/08/11
Reprint requests: Tyler Stevens, MD, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Ave, Desk A31, Cleveland, OH 44195.Cleveland, Ohio, Boston, Massachusetts, Burtonsville, Maryland, USA
Abstract |
Background |
Direct pancreatic function tests (PFT) are conventionally performed with use of double-lumen “Dreiling” collection tubes. We have developed an endoscopic collection method (ePFT) that eases the performance of these tests.
Objective |
Our aim was to compare the bicarbonate results obtained from the secretin ePFT and Dreiling PFT methods in patients evaluated for chronic pancreatitis.
Design |
A prospective crossover design was used to compare the PFT methods.
Setting |
Tertiary care referral center.
Patients and Interventions |
Twenty-four patients undergoing an evaluation for chronic pancreatitis underwent the secretin-stimulated ePFT and Dreiling PFT methods on separate days.
Main Outcome Measurements |
Duodenal fluid bicarbonate concentrations and estimated bicarbonate outputs were compared.
Results |
The mean difference in peak bicarbonate concentration (Dreiling PFT minus ePFT) was 7 mEq/L (SD 20) and not statistically significant (P = .11). A good correlation in peak bicarbonate concentrations (r = 0.74, 95% CI, 0.48-0.88) and estimated bicarbonate output (r = 0.78, 95% CI, 0.54-0.90) was observed between the two PFT methods.
Limitation |
The sensitivities and specificities of the secretin ePFT and Dreiling PFT could not be compared because of the lack of a histologic gold standard.
Conclusion |
The secretin ePFT yields results similar to those of the Dreiling PFT in patients evaluated for chronic pancreatitis.
Le texte complet de cet article est disponible en PDF.Abbreviations : ePFT, PFT, ROC
Plan
| Presented at Digestive Disease Week, May 14-18, 2005, Chicago, Illinois (Gastroenterology 2005;128:A475). |
Vol 67 - N° 3
P. 458-466 - mars 2008 Retour au numéro
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