Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcoming of this method is the difficulty of fixing the knife to the target lesion. It can lead to an unexpected incision and result in major complications, such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping-type scissors forceps (GSF), which can grasp and incise the targeted tissue by using electrosurgical current.

To evaluate the efficacy and safety of ESD by using GSF for the removal of gastric neoplasms in human beings.

Prospective, uncontrolled, single center.

Department of Gastroenterology, Aso Iizuka Hospital, Iizuka, Japan.

Four patients with early gastric neoplastic lesions.

After marking and injection of a solution into the submucosa, the lesion was separated from the surrounding normal mucosa by complete incision around the lesion by using the GSF. A piece of submucosal tissue was grasped and cut with the GSF by using electrosurgical current to achieve submucosal excision.

Technical success and complications.

All lesions were treated easily and safely, without any unexpected incisions. No delayed hemorrhage and perforation occurred. An en bloc resection and a negative resection margin was obtained in all cases.

The small number of patients and an uncontrolled study.

ESD with GSF appeared to be an easy, safe, and technically efficient method for resecting GI neoplasms.