Hereditary Diffuse Gastric Cancer: Prophylactic Surgical Oncology Implications - 23/08/11
Doi : 10.1016/j.suc.2008.04.006
Henry T. Lynch, MD a 
, Edibaldo Silva, MD, PhD b, Debrah Wirtzfeld, MD c, Pamela Hebbard, MD c, Jane Lynch, BSN a, David G. Huntsman, MD d, e, ⁎
, Edibaldo Silva, MD, PhD b, Debrah Wirtzfeld, MD c, Pamela Hebbard, MD c, Jane Lynch, BSN a, David G. Huntsman, MD d, e, ⁎ a Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
b Cancer Center, Creighton University Medical Center, 601 North 30th Street, Omaha, NE 68131, USA
c Memorial University of Newfoundland, PO Box 4200, St. John’s, NL A1C 5S7, Canada
d University of British Columbia, Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
e Department of Pathology, British Columbia Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 1L3, Canada
Corresponding author.Abstract |
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option for CDH1 carriers is prophylactic total gastrectomy, but the variable age of onset of HDGC and the reduced penetrance (about 70%) of the CDHI gene further complicate patients’ decision making.
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| This article was supported by revenue from Nebraska cigarette taxes awarded to Creighton University by the Nebraska Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the State of Nebraska or the Nebraska Department of Health and Human Services. |
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| Support also was given by the National Institutes of Health through grant #1U01 CA 86389. |
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| Dr. Lynch’s work is funded in part through the Charles F. and Mary C. Heider Chair in Cancer Research, which he holds at Creighton University. Dr. Huntsman’s work is funded by the Canadian Cancer Society. |
© 2008
Elsevier Inc. Tous droits réservés.
Vol 88 - N° 4
P. 759-778 - août 2008 Retour au numéro
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