Generic and additional names: Rifabutin

CAS name: 1′,4-didehydro-1-deoxy-1,4-dihydro-5′-(2-methylpropyl)-1-oxorifamycin XIV

CAS registry #: 72559-06-9

Molecular formula: C₄₆H₆₂N₄O₁₁

Molecular weight: 847.005

Intellectual property rights: Generic

Brand names: Ansamycin, Alfacid, Ansatipin, Ansatipine, Antibiotic LM 427, Mycobutin, RBT

Derivatives: KRM-1648 (also called Rifalazil or ABI-1648), rifapentine

Solubility: Rifabutin is a red-violet powder soluble in chloroform and methanol, sparingly soluble in ethanol, and very slightly soluble in water [Merck Index]. Water solubility is 0.19 mg/ml [DrugBank]

Polarity: Log P 4.218 [DrugBank]

Formulation and optimal human dosage: Rifabutin is a spiro-piperidyl-rifamycin derived from rifamycin-S.

Dose 300 mg 1× daily, Capsules 150 mg, Pharmacia