Body Composition and Serum Prostate-Specific Antigen: Review and Findings from Flint Men’s Health Study - 23/08/11
, Gary J. Faerber c, Hal Morgenstern d, David Werny e, Kirk Wojno c, Bronwen Halstead-Nussloch d, Kathleen A. Cooney c, e
Reprint requests: Jennifer Beebe-Dimmer, M.D., Ph.D., Karmanos Cancer Institute, Wayne State School of Medicine, Prentis Building, 110 East Warren Avenue, No. 1115, Detroit, MI 48201.Résumé |
Recent studies have suggested that obesity is associated with lower serum prostate-specific antigen levels, perhaps influencing the recommendation for prostate biopsy and potentially explaining part of the observed poorer prognosis among obese men. African-American men have the greatest rates of prostate cancer and are more likely to die of the disease, making early detection a priority in this group. We present findings from the Flint Men’s Health Study, a study of African-American men, that are consistent with most studies suggesting that overweight men have prostate-specific antigen levels that are 0.15 to 0.30 ng/mL lower than those who are not overweight. We have coupled our results with a systematic review of publications in this area.
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| This work was supported by the National Institutes of Health Specialized Program of Research Excellence (SPORE) grant P50CA89568. |
Vol 71 - N° 4
P. 554-560 - avril 2008 Retour au numéro
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