Fruit and Vegetable Consumption and Its Relation to Markers of Inflammation and Oxidative Stress in Adolescents - 24/08/11
, Antoinette Moran, MD, Samar Basu, PhD, Julia Steinberger, MD, MS, Julie A. Ross, PhD, Ching-Ping Hong, MS, Alan R. Sinaiko, MD
Address correspondence to: Lyn M. Steffen, PhD, MPH, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 South Second St, Suite 300, Minneapolis, MNAbstract |
Background |
Fruits and vegetables, foods rich in flavonoids and antioxidants, have been associated with lower risk of stroke, coronary heart disease, and markers of inflammation and oxidative stress in adults. Markers of inflammation and oxidative stress are predictors of coronary heart disease risk; however, it is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth.
Objective |
To determine whether greater intakes of fruit and vegetables, antioxidants, folate, and total flavonoids were inversely associated with markers of inflammation and oxidative stress in 285 adolescent boys and girls aged 13 to 17 years.
Design |
In this cross-sectional study conducted between February 1996 and January 2000, diet was assessed by a 127-item food frequency questionnaire. Height and weight measurements were obtained and a fasting blood sample drawn. Spearman partial correlation analyses evaluated the relation of intakes of fruit and vegetables, antioxidants, folate, and flavonoids with markers of inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-⍺, and 15-keto-dihydro-PGF2⍺ metabolite and oxidative stress (urinary 8-iso prostaglandin F2⍺, an F2-isoprostane), adjusting for age, sex, race, Tanner stage, energy intake, and body mass index.
Results |
Urinary F2-isoprostane was inversely correlated with intakes of total fruit and vegetables, vitamin C, beta carotene, and flavonoids. Serum C-reactive protein was significantly inversely associated with intakes of fruit (r=−0.19; P=0.004), vitamin C (r=−0.13, P=0.03), and folate (r=−0.18; P=0.004). Serum interleukin-6 was inversely associated with intakes of legumes, vegetables, beta carotene, and vitamin C. Serum tumor necrosis factor-⍺ was inversely associated with beta carotene (r=−0.14, P=0.02) and luteolin (r=−0.15, P=0.02).
Conclusion |
Study results show that the beneficial effects of fruit and vegetable intake on markers of inflammation and oxidative stress are already present by early adolescence and provide support for the Dietary Guidelines for Americans “to consume five or more servings per day” of fruits and vegetables to promote beneficial cardiovascular health.
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Vol 109 - N° 3
P. 414-421 - mars 2009 Retour au numéro
Article précédent
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