Endoscopic transesophageal mediastinal lymph node dissection and en bloc resection by using mediastinal and thoracic approaches (with video) - 24/08/11
Reprint requests: David W. Rattner, MD, Chief of Gastrointestinal Surgery, Department of Surgery, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114Résumé |
Background |
The criterion standard for sampling mediastinal lymph nodes is cervical mediastinoscopy. Current methods that require transthoracic or cervical incisions can result in significant postoperative pain.
Objective |
To determine the feasibility of a novel, transesophageal endoscopic technique for mediastinal lymph node dissection and en bloc resection.
Design |
Nonsurvival and survival animal study.
Setting |
Animal trial at a tertiary-care academic center.
Subjects |
This study involved 12 Yorkshire swine.
Intervention |
An endoscopic cap band mucosectomy device was used to create an esophageal mucosal defect. By using the tip of the endoscope and biopsy forceps, a submucosal tunnel was fashioned, and, within the submucosal space, a hook-knife incised the muscular esophageal wall. The endoscope was then advanced into the mediastinum and chest. Mediastinoscopy and thoracoscopy were performed to identify lymph node stations. Prototype endoscopic devices permitted lymph node dissection prior to removal with an electrocautery snare. A covered prototype stent was placed over the mucosectomy site.
Main Outcome Measurements |
Feasibility of endoscopic transesophageal lymphadenectomy.
Results |
Three lymph nodes (1 para-aortic and 2 right paratracheal) were removed in the 3 nonsurvival swine. Nine swine were survived for 14 days (range 13-14 days) and had a total of 7 lymph nodes (2 para-aortic and 5 paratracheal) removed. Two swine had no endoscopically visible lymph nodes in the mediastinum or chest. Lymph node dissection and resection was successful in all cases where lymph nodes were identified. Lymphadenectomy was completed in a median time of 20.0 minutes (range 8-60 minutes); median total procedure time was 70.0 minutes (range 28-105 minutes). Median lymph node size was 1.1 cm (range 0.6-1.4 cm).
Limitations |
Animal study.
Conclusion |
An endoscopic transesophageal approach can accomplish mediastinal lymph node dissection and en bloc resection and provides architecturally intact lymph node specimens for histologic examination.
Le texte complet de cet article est disponible en PDF.Abbreviations : LN, NOTES
Plan
| DISCLOSURE: Funding for this project was provided by the Center for Integrative Medicine and Technology (B.T., D.G., S.C., P.S. W.R.B., D.W.R.). Ethicon Endo-Surgery donated instruments for this project, and Cook Medical donated endoscopic supplies. W. R. Brugge disclosed a consultant relationship with Boston Scientific, and D. W. Rattner disclosed a speaker relationship with Olympus for which he has received an honorarium. No other disclosures of financial relationships relevant to this publication were made. |
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| The video that accompanies this manuscript was presented orally at the Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons 12th World Congress of Endoscopic Surgery, Washington DC, USA, April 15-17, 2010. |
Vol 72 - N° 4
P. 831-835 - octobre 2010 Retour au numéro
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