Reduced Anterior Cingulate Glutamatergic Concentrations in Childhood OCD and Major Depression Versus Healthy Controls - 24/08/11
, YOUSHA MIRZA, M.D., AILEEN RUSSELL, B.A., JENNIFER TANG, B.S., JANET M. SMITH, B.S., S. PREEYA BANERJEE, PH.D., RASHMI BHANDARI, PH.D., MICHELLE ROSE, B.A., JENNIFER IVEY, B.S., COURTNEY BOYD, M.A., GREGORY J. MOORE, M.D., PH.D.ABSTRACT |
Objective |
To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls.
Method |
Single-voxel proton magnetic resonance spectroscopic examinations of the anterior cingulate cortex were conducted in 14 psychotropic-naïve children and adolescents with MDD without OCD, 10 to 19 years of age, 14 case-matched healthy controls, and 20 nondepressed, psychotropic-naïve pediatric patients with OCD 7 to 19 years of age.
Results |
Anterior cingulate glutamatergic concentrations were significantly reduced in both patients with OCD (15.1% decrease) and patients with MDD (18.7% decrease) compared with controls. Anterior cingulate glutamatergic concentrations did not differ significantly between patients with OCD and those with MDD.
Conclusions |
Altered anterior cingulate glutamatergic neurotransmission may be involved in the pathogenesis of OCD and MDD. These preliminary findings further suggest that reduced anterior cingulate glutamate does not differentiate pediatric patients with OCD from pediatric patients with MDD.
Le texte complet de cet article est disponible en PDF.Key Words : obsessive-compulsive disorder, depression, proton magnetic resonance spectroscopy, anterior cingulate, glutamate
Plan
| This work was supported in part by the State of Michigan Joe F. Young Sr. Psychiatric Research and Training Program, grants from NIMH (MH65122, MH59299, MH02037), NARSAD, the Mental Illness Research Association, the Miriam L. Hamburger Endowed Chair at Children’s Hospital of Michigan, and Wayne State University. The authors are grateful to Drs. Perry Renshaw and Matcheri Keshavan for consultation on the data and to Dr. Joel Ager for statistical consultation. |
Vol 43 - N° 9
P. 1146-1153 - septembre 2004 Retour au numéro
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