Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects - 24/08/11
, Marléne Isaksson, MD, PhD a, Lena Persson, MS a, Erik Zimersson, PhD a, Magnus Bruze, MD, PhD aAbstract |
Background |
Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen.
Objective |
We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects.
Methods |
We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry.
Results |
Photoallergy was demonstrated to ketoprofen, which was detected in personal objects.
Conclusion |
Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers.
Le texte complet de cet article est disponible en PDF.Abbreviations : GC-MS, HPLC, ICDRG, P-F-R 2, PTBP-F-R, TLC, UV
Plan
 | Supported by grants from The Swedish Asthma and Allergy Association's Research Foundation. Conflicts of interest: None identified. |
Vol 50 - N° 2
P. 215-219 - février 2004 Retour au numéro
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