Inflammation, insulin, and endothelial function in overweight children and adolescents: The role of exercise - 24/08/11
, Rachel J. Wetzsteon, BS, Daniel R. Kaiser, PhD, Julia Steinberger, MD, MS, Alan J. Bank, MD, Donald R. Dengel, PhD
Reprint requests: Aaron S. Kelly, PhD, St Paul Heart Clinic, 255 N Smith Ave, Ste 200, St Paul, MN 55102.See editorial, p 719.
Abstract |
Objectives |
To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents.
Study design |
Twenty-five children (body mass index [BMI] >85th percentile) were assessed for brachial artery flow-mediated dilation (FMD), nitroglycerin-induced dilation, C-reactive protein (CRP), lipids, glucose, insulin, oral glucose tolerance, body composition, aerobic fitness (peak oxygen uptake [VO2peak]), and blood pressure. Twenty of these persons were equally and randomly assigned to either 8 weeks of stationary cycling or to a non-exercising control group.
Results |
A baseline correlation was found between CRP and fasting insulin (r=0.62; P < .001), which remained significant after adjusting for baseline variables (r=0.53; P < .05). After 8 weeks, significant improvements were observed in the exercise group compared with the control group for VO2peak (exercise group=21.8 ± 2.1 to 23.2 ± 1.5 mL/kg/minute vs control group=23.4 ± 1.6 to 20.9 ± 2.2 mL/kg/minute; P < .05), high-density lipoprotein (HDL) cholesterol (exercise group=1.02 ± 0.03 to 1.10 ± 0.04 mmol/L vs control group=1.08 ± 0.07 to 0.99 ± 0.09 mmol/L; P < .05), and FMD area under the curve (AUC) (exercise group=746 ± 66 to 919 ± 94 %•sec vs control group=731 ± 102 to 515 ± 73 %•sec; P < .05).
Conclusions |
In overweight children and adolescents, CRP is independently associated with fasting insulin. Eight weeks of aerobic exercise improves fitness, HDL cholesterol, and endothelial function in this group.
Le texte complet de cet article est disponible en PDF.Mots-clés : ANOVA, AUC, BMI, CRP, DBP, FMD, HDL, LDL, SBP, VO2peak
Plan
| Supported in part by Minnesota Obesity Center Grant #: 1 P30 DK 50456-08 (D.R.K.), American Heart Association Pre-Doctoral Grant #: 0315213Z (A.S.K.), and GCRC: M01-RR00400, General Clinical Research Center Program, NCRR/NIH. Data presented in this manuscript appear in a dissertation titled “The effects of aerobic exercise training on vascular structure and function in obese children” that was completed at the University of Minnesota in February 2004. |
Vol 145 - N° 6
P. 731-736 - décembre 2004 Retour au numéro
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