Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children - 24/08/11
, Cynthia Chase, PhD, Richard M. Vezina, MPH, Timothy C. Heeren, PhD, Michael J. Corwin, MD, Sanford H. Auerbach, MD, Debra E. Weese-Mayer, MD, Samuel M. Lesko, MD, MPH
Reprint requests: Daniel J. Gottlieb, MD, MPH, The Pulmonary Center, Boston University School of Medicine, 715 Albany St, R-304, Boston, MA 02118-2394.See editorial, p 430 and related article, p 465
Abstract |
Objective |
To assess the relation of sleep-disordered breathing (SDB) symptoms in children to neurocognitive function.
Study design |
A cross-sectional, population-based study of 205 5-year-old children. A parent-completed questionnaire was used to ascertain SDB symptoms, defined as frequent snoring, loud or noisy breathing during sleep, or witnessed sleep apnea. Polysomnography (PSG) data were available in 85% of children. Standardized neurocognitive tests were administered by a trained psychometrist unaware of the children's SDB status. Children with (n=61) and without SDB symptoms were compared using analysis of variance to adjust for demographic and respiratory health variables.
Results |
Children with SDB symptoms scored significantly lower than those without SDB symptoms on tests of executive function (95.5 vs 99.9 on NEPSY Attention/Executive Core Domain, P=.02; 10.4 vs 11.2 on Wechsler Preschool and Primary Scale of Intelligence, Revised [WPPSI-R] Animal Pegs test, P=.03), memory (96.8 vs 103.0 on NEPSY Memory Domain, P=.02), and general intellectual ability (105.9 vs 111.7 on WPPSI-R Full Scale IQ, P=.02). There were no significant differences on a computerized continuous performance task. These findings persisted when children with PSG evidence of obstructive sleep apnea (OSA) were excluded from analysis.
Conclusion |
Even in the absence of OSA, SDB symptoms are associated with poorer executive function and memory skills and lower general intelligence in 5-year-old children.
Le texte complet de cet article est disponible en PDF.Abbreviations : ADHD, AHI, CPRS, CPT, FYFQ, ICPS, MANOVA, OAI, OSA, PSG, PSQ, SDB, WPPSI-R
Plan
 | Supported by National Heart, Lung and Blood Institute grant HL62371 and by the General Clinical Research Center at Boston University Medical Center (National Center for Research Resources grant RR00533). The Infant Care Practices Study was supported by funds from the National Institute of Child Health and Human Development and the National Institute on Deafness and Other Communicative Disorders under contract HD43221. |
Vol 145 - N° 4
P. 458-464 - octobre 2004 Retour au numéro
Article précédent
- Early onset of subclinical atherosclerosis in young persons with type 1 diabetes
- Jody S. Krantz, Wendy J. Mack, Howard N. Hodis, Chao-Ran Liu, Ci-Hua Liu, Francine R. Kaufman
- Cardiorespiratory events detected by home memory monitoring and one-year neurodevelopmental outcome
- Carl E. Hunt, Michael J. Corwin, Terry Baird, Larry R. Tinsley, Paula Palmer, Rangasamy Ramanathan, David H. Crowell, Susan Schafer, Richard J. Martin, David Hufford, Mark Peucker, Debra E. Weese-Mayer, Jean M. Silvestri, Michael R. Neuman, Jean Cantey-Kiser, the Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group ∗
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