Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction - 25/08/11
Reprint requests: Anthony Odibo, MD, MRCOG, 2000 Ravdin Courtyard, 3400 Spruce St, Philadelphia, PA 19104.Abstract |
Objective |
The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies.
Study design |
This was a case control study of IUGR pregnancies (birth weight <10th percentile for gestational age [GA]) delivered in our unit over 6 years. Cases were compared with controls for the association between abnormal MMS and adverse perinatal outcomes (APO).
Results |
Of the 261 IUGR pregnancies, 39 (16%) had at least 1 APO. An elevated HCG was significantly associated with an APO (OR 2.6, 95% CI 1.1–6.4). A low uE3 was also associated with an APO (OR 5.5, 95% CI 2.2–14). The association between an elevated AFP and APO was not statistically significant (OR 1.6, 95% CI, 0.6–4.6).
Conclusion |
An elevated HCG and low uE3 were associated with APO in cases of IUGR. This information could be useful in identifying a subset of IUGR cases deserving closer surveillance.
Le texte complet de cet article est disponible en PDF.Key words : Intrauterine growth restriction, Perinatal outcomes, Abnormal multiple markers
Plan
| Presented at the Twenty-Fourth Annual Meeting of the Society for Maternal-Fetal Medicine, February 2-7, 2004, New Orleans, La. |
Vol 191 - N° 4
P. 1465-1469 - octobre 2004 Retour au numéro
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