Outcome after invasive recurrence in patients with ductal carcinoma in situ of the breast - 25/08/11
, Laura Klein, M.D. a, Wei Ye, M.S. a, Dennis Holmes, M.D. a, Rashida Soni, M.D. a, Howard Silberman, M.D. a, Michael D. Lagios, M.D. b, Melvin J. Silverstein, M.D. aAbstract |
Background |
Local recurrence is used as a marker of treatment failure for patients with ductal carcinoma in situ (DCIS). As follow-up lengthens, distant recurrence, breast cancer–specific survival (BCSS), and overall survival must be monitored.
Methods |
A prospective database was used to analyze 1031 patients with DCIS. Patients having invasive recurrence after DCIS treatment were compared with patients having infiltrating ductal carcinoma (IDC). End points included distant recurrence, BCSS, and overall survival.
Results |
Overall, patients with DCIS had a BCSS of 99%. BCSS was 85% for patients with invasive recurrences. DDFS in this group was 80%. Stage I IDC patients had a BCSS of 91%, whereas it was 38% in those with stage I IDC and invasive recurrences.
Conclusions |
Most patients with DCIS that recur can be salvaged. For the small subgroup of patients who recur with invasive breast cancer, survival is similar to that of patients with stage IIA IDC.
Le texte complet de cet article est disponible en PDF.Keywords : Breast cancer–specific survival, Ductal carcinoma in situ, Invasive recurrence, Local recurrence
Plan
Vol 188 - N° 4
P. 371-376 - octobre 2004 Retour au numéro
Article précédent
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