Contralateral prophylactic mastectomy in breast cancer patients who test negative for BRCA mutations - 25/08/11
, Rebecca W. Schroll, M.D., Gail J. Hurt, B.S.N., Edward A. Levine, M.D.
Corresponding author. Tel.: +1-336-716-9283; fax: +1-336-716-9758Abstract |
Background |
Determination of BRCA1 and 2 mutation carrier status is important. Although BRCA carriers are offered bilateral mastectomy and oophorectomy, most who test negative decline. Some women choose contralateral prophylactic mastectomy (CPM) at the time of their breast cancer diagnosis despite testing negative.
Methods |
A total of 110 women with breast cancer received genetic testing before surgical treatment. Patient demographics, tumor characteristics, surgical treatment, and magnetic resonance imaging use were recorded.
Results |
Results revealed BRCA1/2 mutation in 33%, variant of unknown significance in 6%, and no mutation in 61% of women. In BRCA-negative women, 37% chose CPM. Marital status was significant for CPM (P = .03). Race, age, stage of presentation, and biomarker status were not associated with choice of CPM. Ninety-six percent of CPM recipients underwent breast reconstruction. Magnetic resonance imaging use did not affect CPM rates (P = .99).
Conclusions |
Increased rates of CPM have been observed. In our study married women were more likely to choose CPM. We recommend genetic genotyping before surgery. These findings warrant further investigation.
Le texte complet de cet article est disponible en PDF.Keywords : Contralateral prophylactic mastectomy, BRCA negative, Breast cancer
Plan
Vol 202 - N° 3
P. 298-302 - septembre 2011 Retour au numéro
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