Cerebral infarction in eclampsia - 25/08/11
, James L Fleckenstein, MD b, Diane M Twickler, MD b, F.Gary Cunningham, MD a
Reprint requests: G. G. Zeeman, MD, Department of Obstetrics and Gynecology, Division of Perinatology, Isala Clinics, Sophia Hospital, Dr. Van Heesweg 2, 8025 AB Zwolle, The Netherlands. Abstract |
Objective |
This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI).
Study design |
During the 3-year period ending March 2002, 27 nulliparous women with eclampsia were evaluated with diffusion-weighted MRI and apparent diffusion coefficient mapping. Those with findings of restricted diffusion suggestive of cytotoxic edema underwent neuroimaging again 6 weeks post partum.
Results |
All but 2 of these 27 women (93%) had reversible vasogenic edema. Six were also found to have areas of cytotoxic edema consistent with cerebral infarction. Five of these 6 women had persistent imaging findings of infarction when studied post partum, however, without clinical neurologic deficits.
Conclusion |
The spectrum of cerebral lesions in eclampsia as seen with MRI varies from initially reversible areas of vasogenic edema that may progress to cytotoxic edema and infarction in up to a fourth of women.
Le texte complet de cet article est disponible en PDF.Keywords : Eclampsia, Hypertensive encephalopathy, Cerebral infarction, Magnetic resonance imaging, Diffusion-weighted imaging
Plan
Vol 190 - N° 3
P. 714-720 - mars 2004 Retour au numéro
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