Association between hyperhomocysteinemia and primary pulmonary hypertension - 26/08/11
, Sunder Sandur a, Donald W. Jacobsen b, Sanjiv Tewari a, Masroor Mustafa d, Edward J. Mascha c, Killian Robinson eAbstract |
Study objective: This case-control study was conducted to test the hypothesis that fasting homocysteine levels are higher in PPH patients than in healthy controls. Design: Levels of plasma total homocysteine, serum folate, vitamin B-12, and serum creatinine in 18 consecutive patients with PPH were compared with data from 36 age- and sex-matched controls. Results: Eight of the 18 patients (44.4%) and three of the 36 controls (8.3%) had elevated plasma total homocysteine (tHcy) levels (⩾15μmol/l, odds ratio 8.8; 95% CI: 2.0–39.6; P=0.005). There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P=0.036). Conclusion: PPH patients are significantly more likely to have hyperhomocysteinemia, and higher mean plasma total homocysteine levels than in controls. Plasma total homocysteine may be an important factor in the pathogenesis of PPH.
Le texte complet de cet article est disponible en PDF.Keywords : Hyperhomocysteinemia, Primary pulmonary hypertension
Plan
Vol 97 - N° 7
P. 825-829 - juillet 2003 Retour au numéro
Article précédent
- Non-invasive mechanical ventilation improves walking distance but not quadriceps strength in chronic respiratory failure
- Bernd Schönhofer, Christoph Zimmermann, Piotr Abramek, Stefan Suchi, Dieter Köhler, Michael I Polkey
- Should flow-volume loop be monitored in sleep apnea patients treated with continuous positive airway pressure?
- Marcel Bonay, Alain Nitenberg, Dominique Maillard
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?