Endothelial cell function in patients with Down's syndrome - 26/08/11
, Giuseppe Santoro, MD a, Carmine Battaglia, MD a, Maria Teresa Palladino, MD a, Marianna Carrozza, MD a, Maria Giovanna Russo, MD a, Giuseppe Pacileo, MD a, Raffaele Calabrò, MD aAbstract |
Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.
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Vol 94 - N° 3
P. 392-395 - août 2004 Retour au numéro
Article précédent
- Comparison of echocardiographic features of noncompaction of the left ventricle in adults versus idiopathic dilated cardiomyopathy in adults
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- Wojciech Kosmala, Wojciech Kucharski, Monika Przewlocka-Kosmala, Walentyna Mazurek
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