Platelet aggregation inhibition blocks C-reactive protein and interleukin-6 (IL-6) elevation after the coronary angioplasty: Effect of the −174 G/C IL-6 gene polymorphism - 26/08/11
Doi : 10.1016/j.amjcard.2004.07.119
Alvaro Merino, MD, PhD a, ⁎ 
, Antonio Gayá, MD, PhD b, Ignacio Segura, MD a, Javier Calvo, MD, PhD b, Cristina Imízcoz, RN a, Alejandro Berenguel, MD a, Eduardo Alegría, MD, PhD c
, Antonio Gayá, MD, PhD b, Ignacio Segura, MD a, Javier Calvo, MD, PhD b, Cristina Imízcoz, RN a, Alejandro Berenguel, MD a, Eduardo Alegría, MD, PhD c a Institut Cardiologic, Clínica Rotger, Mallorca, Spain
b Banc de Sang I Teixits de Ses Illes Balears, Mallorca, Spain
c Clínica Universitaria de Navarra, Pamplona, Spain
*Dr. Merino's address is: Clínica Rotger, C/ Santiago Rusiñol, 9, 07012 Palma de Mallorca, Spain
Résumé |
C-reactive protein (CRP), interleukin-6 (IL-6), and the −174 GC IL-6 gene polymorphism were analyzed after coronary angioplasty in 50 patients, 25 of whom were treated with the glycoprotein IIb/IIIa platelet receptor inhibitor eptifibatide for 24 hours. It was found that glycoprotein IIb/IIIa inhibition significantly blocked postangioplasty CRP increases in all patients but blocked IL-6 increases only in patients carrying the −174 GG genotype.
Le texte complet de cet article est disponible en PDF.| This work was supported by a research grant from the Spanish Society of Cardiology, Madrid, Spain. |
© 2004
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Vol 94 - N° 10
P. 1300-1303 - novembre 2004 Retour au numéro
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