Positron emission tomography scanning in essential blepharospasm - 26/08/11

Doi : 10.1016/S0002-9394(03)00895-X

John B Kerrison, MD ^a,^⁎ , Jack L Lancaster, PhD ^b, Frank E Zamarripa, BS ^b, Londe A Richardson, MD ^c, John C Morrison, MD ^c, David E.E Holck, MD ^a, Kurt W Andreason, MD ^a, Sean M Blaydon, MD ^d, Peter T Fox, MD ^b
^a Ophthalmology (J.B.K., D.E.E.H., K.W.A.), Wilford Hall Medical Center, Lackland AFB, Lackland, Texas, USA
^c Nuclear Medicine (L.A.R., J.C.M.), Wilford Hall Medical Center, Lackland AFB, San Antonio, Texas, USA
^b Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA (J.L.L., F.E.Z, P.T.F.)
^d Department of Ophthalmology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas, USA (S.M.B.)

^*Inquiries to John B. Kerrison, MD, Wilmer Eye Institute, Johns Hopkins Hospital, 600 North Wolfe St., Maumenee B109, Baltimore, MD 21287, USA; fax: (410) 614-9240

Abstract

Purpose

To localize in the brain using positron emission tomography neuroimaging with ¹⁸fluorodeoxyglucose [PET (¹⁸FDG)] differences in glucose metabolism between patients with essential blepharospasm (EB) and controls.

Design

Prospective case-control study

Methods

Positron emission tomography neuroimaging with ¹⁸fluorodeoxyglucose was performed in 11 patients with EB and 11 controls matched for age and gender. Global analysis of images was used to localize differences in glucose metabolism between groups.

Results

Multiple cortical and subcortical abnormalities were observed in EB patients in comparison with controls. Cortical areas with the largest and most significant clusters of increased glucose uptake were the inferior frontal gyri, right posterior cingulate gyrus, left middle occipital gyrus, fusiform gyrus of the right temporal lobe, and left anterior cingulate gyrus. Cortical areas with the largest and most significant clusters of decreased glucose uptake were the inferior frontal gyri, ventral to the area of increased glucose metabolism. Subcortical abnormalities, consisting of increased glucose uptake, involved the right caudate and consisting of decreased glucose uptake, involved the left inferior cerebellar hemisphere and thalamus.

Conclusions

Global analysis of positron emission tomography neuroimaging with ¹⁸fluorodeoxyglucose neuroimaging in EB patients in comparison with controls demonstrates a pattern of abnormalities involving several cortical and subcortical areas that control blinking, including the inferior frontal lobe, caudate, thalamus, and cerebellum.

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Plan

Supported by a grant (FWH20010122H) from the Office of the Surgeon General of the United States Air Force. The features expressed in the article are those of the authors and do not reflect the official policy of the Department of Defense or other departments of the United States government.

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Vol 136 - N° 5

P. 846-852 - novembre 2003 Retour au numéro

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Positron emission tomography scanning in essential blepharospasm - 26/08/11

Abstract

Purpose

Design

Methods

Results

Conclusions

Plan

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