Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery - 28/08/11
, Lourdes Vadillo-Perez a, Ana Hernandez-Carbajal, BSc a, c, Myrna Godines-Enriquez, MD, MSc d, David M. Olson, PhD, FRCOG b, Felipe Vadillo-Ortega, MD, PhD e
Reprints: Nardhy Gomez-Lopez, MSc, PhD, PreHOT, 227 HMRC, University of Alberta, Edmonton, Canada, T6G2S2Résumé |
Objective |
The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery.
Study Design |
Fetal membrane explants from postrupture zones (periplacental, middle, rupture) were obtained from women following spontaneous vaginal delivery at term (n = 5). Tissues for histology, protein extracts, and RNA were isolated.
Results |
The collagen distribution decreased and the leukocyte density increased from the periplacental zone to the rupture zone. T cells were mainly present in the rupture zone and granulocytes in the middle zone. CXCL10, CXCR1, ICAM-1, -2, PSEL, tumor necrosis factor alpha, and matrix metalloproteinase-9 levels were higher in the middle zone than in the rupture zone and periplacental zone (P < .021). Interleukin-1beta and CXCL8 levels were higher in the rupture zone than in the middle zone and periplacental zone (P = .018 and P < .0001).
Conclusion |
During labor specific immunologic microenvironments are created in the zones of the fetal membrane that may be involved in their rupture at the end of gestation.
Le texte complet de cet article est disponible en PDF.Key words : fetal membrane zones, inflammation, parturition
Plan
| D.M.O. and N.G.L. were supported by the Alberta Innovates-Health Solutions Interdisciplinary Preterm Birth and Healthy Outcomes Team award (to D.M.O.). F.V.O. was supported by CONACyT-SALUD 7036 and 69353. |
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| Cite this article as: Gomez-Lopez N, Vadillo-Perez L, Hernandez-Carbajal A, et al. Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery. Am J Obstet Gynecol 2011;205:235.e15-24. |
Vol 205 - N° 3
P. 235.e15-235.e24 - septembre 2011 Retour au numéro
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