Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension - 28/08/11
Doi : 10.1016/S0002-9149(03)00910-X
D.Dunbar Ivy, MD a, ⁎ 
, Donna Parker, RRT, Aimee Doran, CPNP a, Donna Parker, RRT b, John P. Kinsella, MD c, Steven H. Abman, MD b
, Donna Parker, RRT, Aimee Doran, CPNP a, Donna Parker, RRT b, John P. Kinsella, MD c, Steven H. Abman, MD b a Section of Cardiology, Denver, Colorado, USA
b Section of Pulmonology, Denver, Colorado, USA
c Section of Neonatology, Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children's Hospital, Denver, Colorado, USA
*Dr. Ivy's address is: B-100, Pediatric Cardiology, The Children's Hospital, 1056 East Nineteenth Avenue, Denver, Colorado 80218-1088, USA.
Abstract |
In 26 patients, we evaluated a novel pulsed nasal delivery system for nitric oxide (NO) that, in the short term, was as effective as continuous delivery for decreasing pulmonary artery pressure and pulmonary vascular resistance. In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied.
Le texte complet de cet article est disponible en PDF. | This research was supported by grant number MO1 RR00069, General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland. Study gas and the inhaled nitric oxide pulsed delivery systems were provided by INO Therapeutics, Clinton, New Jersey. |
© 2003
Excerpta Medica Inc. Tous droits réservés.
Vol 92 - N° 7
P. 886-890 - octobre 2003 Retour au numéro
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