Intra-amniotic corticosteroids for preterm lung maturation in sheep - 28/08/11
, Neil P Mulrooney, MD b, Ilias Nitsos, PhD a, Machiko Ikegami, PhD, MD b, Alan H Jobe, PhD, MD b, John P Newnham, MD a
Reprint requests: T. J. M. Moss, PhD, Lotteries Commission Perinatal Research Laboratories, School of Women's and Infants' Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley WA 6009, Australia.Abstract |
Objective |
The purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone.
Study design |
Pregnant ewes received intra-amniotic betamethasone (0.5 mg/kg or 2 mg/kg fetal weight), intra-amniotic budesonide (0.5 mg/kg or 2 mg/kg), maternal intramuscular betamethasone (0.5 mg/kg maternal weight), intra-amniotic saline solution, or maternal saline solution. Lambs were delivered 2 or 7 days later, at 124 days of gestation for measurement of respiratory system compliance, ventilatory efficiency index, and surfactant levels.
Results |
Lung function increased 2 days after maternal betamethasone, intra-amniotic betamethasone (2 mg/kg), and intra-amniotic budesonide (2 mg/kg) administration and 7 days after maternal betamethasone or intra-amniotic budesonide (2.0 mg/kg) administration. Lung function was not improved 7 days after intra-amniotic betamethasone (2.0 mg/kg) administration or 2 days after intra-amniotic betamethasone (0.5 mg/kg) or intra-amniotic budesonide (0.5 mg/kg) administration. Intra-amniotic corticosteroid administration increased fetal death and respiratory morbidity.
Conclusion |
Intra-amniotic corticosteroid administration improved preterm lung function, but the associated morbidity and mortality rates suggest that they are not suitable for clinical use.
Le texte complet de cet article est disponible en PDF.Keywords : Antenatal corticosteroid, lung maturation, preterm labor, sheep
Plan
 | Supported by grant No. HD-65397 from the National Institutes of Child Health and Development and by the Child Health Research Foundation of Western Australia. |
Vol 189 - N° 5
P. 1389-1395 - novembre 2003 Retour au numéro
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