Response of fetal prostanoids, nitric oxide, and ductus arteriosus to the short- and long-term antenatal administration of celecoxib, a selective cyclo-oxygenase-2 inhibitor, in the pregnant rabbit - 29/08/11
Reprint requests: Tamerou Asrat, MD, Division of Perinatal Medicine, Women's Hospital, Long Beach Memorial Medical Center, 2801 Atlantic Ave, Long Beach, CA 90801-1428.Abstract |
Objective |
The purpose of this study was to test the hypothesis that the maternal administration of therapeutic doses of celecoxib would not affect ductus arteriosus patency or alter renal and hepatic prostanoids in the fetal rabbit.
Study design |
Pregnant rabbits received celecoxib from 13 to 20 days (celecoxib-A), from 13-28 days (celecoxib-B), or vehicle from 13 to 28 days by gavage. Fetal serum and lung tissue were analyzed for nitric oxide oxidation products. Fetal plasma, liver, and kidney were analyzed for prostaglandin levels.
Results |
The ductus arteriosus was patent in both treatment groups. Celecoxib induced elevations of plasma prostaglandin E2 production. In celecoxib-B liver and kidney, the 6-keto-prostaglandin F1⍺ and prostaglandin F2⍺ levels were increased, and the prostaglandin E2 and thromboxane B2 levels were decreased substantially.
Conclusion |
This preliminary evaluation demonstrates that the maternal administration of celecoxib does not influence fetal ductus arteriosus patency adversely in rabbits.
Le texte complet de cet article est disponible en PDF.Keywords : Celecoxib, ductus arteriosus, kidney, liver, nitric oxide, prostanoids
Plan
 | Supported by a grant from the Long Beach Memorial Medical Center Foundation, Long Beach, Calif. Presented in part at the Forty-Eighth Annual Meeting of the Society for Gynecologic Investigation, Toronto, Ontario, Canada, 2001, and at the Seventy-Second Annual Meeting of the Society for Pediatric Research, Baltimore, Md, 2001. |
Vol 189 - N° 6
P. 1744-1750 - décembre 2003 Retour au numéro
Article précédent
- Effect of the antenatal administration of celecoxib during the second and third trimesters of pregnancy on prostaglandin, cytokine, and nitric oxide levels in rabbits
- Nicole Hausman, Kay D Beharry, Kenji C Nishihara, Yasir Akmal, Tamerou Asrat
- Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration
- Timothy J.M Moss, Dorota A Doherty, Ilias Nitsos, Richard Harding, John P Newnham
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?