Chorioamnionitis induced by subchorionic endotoxin infusion in sheep - 29/08/11
, Ilias Nitsos, PhD a, John P Newnham, MD a, Machiko Ikegami, PhD, MD b, Alan H Jobe, PhD, MD b
Reprint requests to: T. J. M. Moss, PhD, Lotteries Commission Perinatal Research Laboratories, School of Women's and Infants' Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley WA 6009, Australia.Abstract |
Objective |
This study was undertaken to determine whether subchorionic endotoxin infusion causes chorioamnionitis and preterm lung maturation, as occurs after intra-amniotic endotoxin.
Study design |
From day 118 of pregnancy, sheep received infusions of endotoxin (subchorionic 7.5 mg/d, n=11; intra-amniotic 2.5 mg/d, n=9) until delivery of lambs at 120 or 124 days. Other sheep received a single intra-amniotic injection of endotoxin (10 mg, n=7) at 118 days before delivery at 124 days. Controls (n=9) received equivalent saline solution treatments.
Results |
Chorioamnionitis accompanied all endotoxin treatments. Lung inflammation occurred after intra-amniotic endotoxin infusion or injection but not after subchorionic endotoxin. Umbilical arterial pH was lower and Pco2 was higher than control after subchorionic endotoxin. Lung compliance and surfactant were increased after intra-amniotic endotoxin infusion or injection but not after subchorionic endotoxin.
Conclusion |
Chorioamnionitis may result from inflammatory stimuli at various intrauterine sites, with different sites causing different fetal effects and not all cases of chorioamnionitis being accompanied by enhanced lung maturation.
Le texte complet de cet article est disponible en PDF.Keywords : Preterm birth, intrauterine inflammation, respiratory distress syndrome, fetal maturation, sheep
Plan
 | Supported by grant No. HD-65397 from the National Institutes of Child Health and Development. |
Vol 189 - N° 6
P. 1771-1776 - décembre 2003 Retour au numéro
Article précédent
- Correction
- Human maternal and fetal plasma glyceryl trinitrate concentrations
- Mark A Bustard, Greg Ryan, Gareth Seaward, Mary-Ellen Saleniak, Graeme N Smith
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?