Are all ⍺-blockers created equal? An update - 31/08/11
Abstract |
⍺-Receptor blockers, used to treat lower urinary tract symptoms, exert effects on areas of the body other than the prostate where ⍺-receptors are located, including the blood vessels and the central nervous system. ⍺-Receptors in the central and peripheral nervous system may be involved in bladder activation. ⍺1a-Receptors are the appropriate target in men with obstructive symptoms, although ⍺1d-receptors may also be important in patients with irritative symptoms. There is conflicting evidence about the selectivity of ⍺-blockers. Clinical trials of these agents do not necessarily reflect results observed in animal and laboratory studies on uroselectivity. The few published comparator studies of ⍺-blockers indicate similar efficacies, although side-effect profiles differ somewhat. Randomized, controlled studies of different ⍺-blockers with sufficient power to detect differences in side effects between agents are needed.
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Vol 59 - N° 2S1
P. 3-6 - février 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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