Hyperzincemia with systemic inflammation: A heritable disorder of calprotectin metabolism with rheumatic manifestations? - 01/09/11
Doi : 10.1067/mpd.2002.121699
Yoshiaki Saito, MD, Kayoko Saito, MD, Yukiko Hirano, MD, Kiyoko Ikeya, MD, Haruko Suzuki, MD, Keiko Shishikura, MD, Sumie Manno, PhD, Yuichi Takakuwa, PhD, Kiyoshi Nakagawa, PhD, Aiko Iwasa, PhD, Satoshi Fujikawa, MD, Makoto Moriya, MD, Nobuyuki Mizoguchi, MD, Barbara E. Golden, MD, Makiko Osawa, MD
Grampian, Scotland
From the Departments of Pediatrics, Biochemistry, and Chemistry, and the Institute of Rheumatology, Tokyo Women’s Medical University (TWMU), the Department of Pediatrics, Mitsubishi Mihara Hospital, Japan; and the Department of Child Health, University of Aberdeen, Grampian, Scotland
Abstract |
A boy had infantile-onset systemic inflammation, growth failure, hepatosplenomegaly, anemia, leukocytopenia, progressive muscular dystrophy, and hypercalprotectinemia, resulting in marked hyperzincemia. His mother had a history of chronic arthritis since childhood and also showed hypercalprotectinemia/hyperzincemia. We postulate an inherent defect in calprotectin metabolism. (J Pediatr 2002;140:267-9)
Le texte complet de cet article est disponible en PDF.Abbreviations : CK, CRP
Plan
| ☆ | Supported by grant No. 11-9-09, Ministry of Health, Welfare, and Sports of Japan. |
| ☆☆ | Reprint requests: Yoshiaki Saito, Department of Pediatrics, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. |
© 2002
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Vol 140 - N° 2
P. 267-269 - février 2002 Retour au numéro
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