The diagnosis and treatment of liver lesions has improved during the past decade. Major liver resections can now be performed with minimal mortality and low morbidity, and alternate approaches such as enucleation, cryoablation, and radiofrequency ablation are now available. Hepatic artery embolization and portal vein embolization have allowed preoperative downstaging of some tumors and the remodeling and hypertrophy of normal hepatic parenchyma in preparation for major resection. An accurate diagnosis and a precise determination of the extent of disease are therefore pivotal in the evaluation of newly diagnosed liver lesions.