Bradykinin sensitivity in primary open-angle glaucoma and normal-tension glaucoma patients - 02/09/11
, Fumio Shiraga, MD a, Eiichi Hasegawa, MD aAbstract |
Purpose |
To report the reaction after intradermal injection of bradykinin in nonglaucoma, primary open-angle glaucoma, and normal-tension glaucoma subjects.
Design |
Prospective comparative study.
Methods |
The study participants were 14 healthy control subjects, 16 patients with primary open-angle glaucoma, and 15 patients with normal-tension glaucoma. In each participant, the wheal response to intradermal injection of 10 μg bradykinin in the volar forearm was measured by a masked observer.
Results |
There was no significant difference in the wheal response to bradykinin between control subjects and primary open-angle glaucoma patients (P = .73) and between primary open-angle glaucoma patients and normal-tension glaucoma patients (P = .09). However, there was a significant difference in the wheal response to bradykinin between control subjects and normal-tension glaucoma patients (P = .04).
Conclusions |
These in vivo structure-activity studies may suggest abnormalities of the tissue kallikrein-kinin system in normal-tension glaucoma.
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Vol 134 - N° 6
P. 922-924 - décembre 2002 Retour au numéro
Article précédent
- Morphometric change analysis of the optic nerve head in unilateral disk hemorrhage cases
- Jae Kyoun Ahn, K.i H.o Park
- Changes of ocular aberration with accommodation
- Sayuri Ninomiya, Takashi Fujikado, Teruhito Kuroda, Naoyuki Maeda, Yasuo Tano, Tetsuro Oshika, Yoko Hirohara, Toshifumi Mihashi
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