Fluoroquinolones have been used for more than 20 years in the United States; however, rarely have pediatricians prescribed these agents. With the increasing threat of resistant bacteria, and with the superior serum levels achieved with oral administration, these agents are increasingly being considered for use in the pediatric population. This article reviews the current data from clinical trials in adults, as well as provides information on the use of these agents in the pediatric population. Currently, on-going trials are determining whether the fluoroquinolones are safe and efficacious in children. Copyright © 2001 by W.B Saunders Company