Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE) - 02/09/11
, Marian B Olson, MS b, B.Delia Johnson, PhD b, Vera Bittner, MD, MPH c, T.Keta Hodgson, RN a, Sarah L Berga, MD d, Glenn D Braunstein, MD a, Carl J Pepine, MD e, Steven E Reis, MD f, George Sopko, MD g, Sheryl F Kelsey, PhD bAbstract |
Purpose |
Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that use of statins and the resultant lower blood lipoprotein levels would be associated with lower reproductive hormone levels in women. We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age.
Methods |
We enrolled 453 (114 pre-, 30 peri-, and 309 postmenopausal) women with coronary risk factors (mean [± SD] age, 58 ± 13 years) who were undergoing coronary angiography for suspected ischemia at four academic medical centers. Blood lipoprotein levels (total cholesterol, triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol) and serum reproductive hormone levels (estradiol, bioavailable estradiol, estrone, progesterone) were measured.
Results |
Use of statins was associated with lower lipoprotein levels, but not lower reproductive hormone levels, in all women. Mean estradiol levels were not significantly lower among premenopausal women with very low LDL cholesterol levels compared with women with higher LDL cholesterol levels (estradiol: 71 ± 52 pg/mL vs. 88 ± 67 pg/mL, P = 0.32).
Conclusion |
Among women undergoing coronary angiography for suspected myocardial ischemia, the use of statins, or lower cholesterol levels, are not associated with significantly lower levels of reproductive hormones.
Le texte complet de cet article est disponible en PDF.Plan
 | This work was supported by The Women’s Guild of Cedars-Sinai Medical Center, Los Angeles, California; contracts N01-HV-68161, N01-HV-68162, N01-HV-68163, and N01-HV-68164 from the National Heart, Lung and Blood Institutes, Bethesda, Maryland; and a General Clinical Research Center grant MO1-RR00425 from the National Center for Research Resources, Bethesda, Maryland; in addition to grants from the Gustavus and Louis Pfeiffer Research Foundation, Denville, New Jersey, and The Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania. |
Vol 113 - N° 9
P. 723-727 - décembre 2002 Retour au numéro
Article précédent
- Use of cytosolic and myofibril markers in the detection of ongoing myocardial damage in patients with chronic heart failure
- Koichi Setsuta, Yoshihiko Seino, Takeshi Ogawa, Masato Arao, Yoshiko Miyatake, Teruo Takano
- Conservative management of polymicrobial peritonitis complicating peritoneal dialysis—a series of 140 consecutive cases
- Cheuk-Chun Szeto, Kai-Ming Chow, Teresa Yuk-Hwa Wong, Chi-Bon Leung, Philip Kam-Tao Li
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?