OBSESSIVE-COMPULSIVE DISORDER AND TIC SYNDROMES - 02/09/11

Doi : 10.1016/S0025-7125(05)70338-2

Neal R. Swerdlow, MD, PhD ^{^{*
Department of Psychiatry, University of California San Diego, La Jolla, California}}

Résumé

Interconnected cortico-striato-pallido-thalamic (CSPT) circuitry long has been implicated in the regulation of movement, thought, and affect; abnormalities within this circuitry have been proposed to contribute to the pathophysiology of many neuropsychiatric disorders. The motor loops of CSPT circuitry are known to be the locus of pathology in primary movement disorders, such as Huntington's disease,^{79 Reiner A., Albin R.L., Anderson K.D. , et al. Differential loss of striatal projection neurons in Huntington disease Proc Natl Acad Sci U S A 1988 ; 85 : 5733-5737 [cross-ref]

Cliquez ici pour aller à la section Références} Parkinson's disease,^{38 Javoy-Agid F., Ruberg M., Taquet H. , et al. Biochemical neuropathology of Parkinson’s disease Adv Neurol 1984 ; 40 : 189-198

Cliquez ici pour aller à la section Références} and hemiballism,^{57 Marsden C.D. Motor disorders in basal ganglia disease Hum Neurobiol 1984 ; 2 : 245-255

Cliquez ici pour aller à la section Références} and the limbic CSPT loops have been proposed as the source of pathology in schizophrenia,^{103 Swerdlow N.R., Koob G.F. Dopamine, schizophrenia, mania and depression: Toward a unified hypothesis of cortico-striato-pallido-thalamic function Behav Brain Sci 1987 ; 10 : 197-245 [cross-ref]

Cliquez ici pour aller à la section Références} depression,^{103 Swerdlow N.R., Koob G.F. Dopamine, schizophrenia, mania and depression: Toward a unified hypothesis of cortico-striato-pallido-thalamic function Behav Brain Sci 1987 ; 10 : 197-245 [cross-ref]

Cliquez ici pour aller à la section Références} Tourette Syndrome (TS),^{95 Singer H.S. Neurobiology of Tourette syndrome Neurol Clin North Am 1997 ; 15 : 357-379 [cross-ref]

Cliquez ici pour aller à la section Références} obsessive-compulsive disorder (OCD),^{7 Baxter L.R., Schwartz J.M., Bergman , et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder Arch Gen Psychiatry 1992 ; 49 : 681-689

Cliquez ici pour aller à la section Références, 89 Schwartz J.M., Stoessel P.W., Baxter L.R.J. , et al. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder Arch Gen Psychiatry 1996 ; 53 : 109-113

Cliquez ici pour aller à la section Références} attention-deficit/hyperactivity disorder (ADHD),^{13 Castellanos F.X. Toward a pathophysiology of attention-deficit/hyperactivity disorder Clin Pediatr 1997 ; 36 : 381-393 [cross-ref]

Cliquez ici pour aller à la section Références} substance abuse disorders,^{60 Modell J.G., Mountz J.M., Beresford T.P. Basal ganglia/limbic striatal and thalamocortical involvement in craving and loss of control in alcoholism J Neuropsychiatr Clin Neurosci 1990 ; 2 : 123-144

Cliquez ici pour aller à la section Références} temporal lobe epilepsy,^{111 Van Paesschen W., Revesv T., Duncan J.S. , et al. Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy Ann Neurol 1997 ; 42 : 756-766 [cross-ref]

Cliquez ici pour aller à la section Références} and many other seemingly disparate forms of psychopathology. Overlapping anatomic models for these disorders have been accompanied by blurred boundaries at a clinical level, with commonalities identified in symptoms and treatment responsivity among many of these disorders. OCD and TS are perhaps the two most closely connected among the disorders associated with CSPT pathology. OCD and TS are linked by overlapping symptoms, frequent comorbidity, and cosegregation in families. Clinically, there are important similarities and differences between these two disorders (Table 1)

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Plan

OBSESSIVE-COMPULSIVE DISORDER

Neuroimaging

In Vivo Neurochemistry

Preliminary Neuropathology Studies

Neuroimaging

In Vivo Neurochemistry

Pathophysiology

Genetics

Therapeutic Interventions

SUMMARY

Address reprint requests to Neal R. Swerdlow, MD, PhD, Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093–0804. e-mail: nswerdlow@ucsd.edu
The author is supported by NIMH Award MH 01436.

Topics covered in this article have been reviewed in previous reports by the author.^{103 Swerdlow N.R., Leckman J.F. Tourette’s syndrome and related tic disorders. Fifth Generation of Progress. American College of Neuropsychopharmacology Baltimore, MD: Lippincott Williams & Wilkins (2000).
in press.

Cliquez ici pour aller à la section Références, 105 Swerdlow N.R., Young A.B. Neuropathology in Tourette syndrome CNS Spectrums 1999 ; 4 : 65-74

Cliquez ici pour aller à la section Références}