Médecine

Paramédical

Autres domaines


S'abonner

Correlation between 8-methoxypsoralen bath-water concentration and photosensitivity in bath-PUVA treatment - 02/09/11

Doi : 10.1067/mjd.2001.112360 
Adrian Tanew, MD a, Tanja Kipfelsperger, MD a, Arno Seeber, MD b, Sonja Radakovic-Fijan, MD a, Herbert Hönigsmann, MD a
a Division of Special and Environmental Dermatology, Department of Dermatology, University of Vienna Medical School Vienna, Austria 
b Department of Dermatology, Donauspital/SMZ-Ost. Vienna, Austria 

Abstract

Background: Bath-PUVA treatment, originally established in Scandinavia, offers several advantages over oral PUVA and has become increasingly popular in recent years. Outside Scandinavia 8-methoxypsoralen (8-MOP) is the prevailing photosensitizer for this PUVA modality and is used arbitrarily in a wide range of concentrations. Up to the present, data are lacking on the impact of 8-MOP bath-water concentration on UVA dosimetry. Objective: We investigated the influence of increasing 8-MOP bath-water concentrations on photosensitivity in bath-PUVA treatment. Methods: Fifteen healthy volunteers without abnormal photosensitivity or recent exposure to ultraviolet radiation were included in an intraindividually controlled comparison study. In all volunteers the minimal phototoxic dose (MPD) was determined on the volar side of their forearms after immersion for 20 minutes in 4 different 8-MOP bath-water concentrations (0.5, 1, 2.5, and 5 mg/L). The correlation between 8-MOP concentration and photosensitivity (defined as the reciprocal value of the MPD) was analyzed by linear regression analysis. In addition, the time course of erythema formation and the UVA dose-erythema response curve was assessed for each psoralen concentration. Results: The median MPD and the 25%-75% interquartile were 5.7 J/cm2 (5.7-8), 4 J/cm2 (4-5.7), 2.8 J/cm2 (2.8-5.7), and 2 J/cm2 (2-2.8) at an 8-MOP concentration of 0.5, 1, 2.5, and 5 mg/L, respectively. Linear regression analysis revealed a significant correlation between 8-MOP bath-water concentration and photosensitivity (r = 0.98; P = .019). Bath-PUVA-induced erythema peaked after a median time interval of 3 days, with a range of 2 to 4 days. The slope of the UVA dose-erythema response curve was similar for all psoralen concentrations. Conclusion: UVA dose requirements in bath-PUVA treatment decrease linearly with increasing 8-MOP concentrations. A single MPD assessment at 72 hours after the UVA exposure is inappropriate for accurate determination of the patients' photosensitivity. The hazard of wrong UVA dosimetry is comparable at all psoralen concentrations. (J Am Acad Dermatol 2001;44:638-42.)

Le texte complet de cet article est disponible en PDF.

Plan


 Reprint requests: Adrian Tanew, MD, Division of Special and Environmental Dermatology, Department of Dermatology, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
 J Am Acad Dermatol 2001;44:638-42


© 2001  American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 44 - N° 4

P. 638-642 - avril 2001 Retour au numéro
Article précédent Article précédent
  • Experience with calcipotriol as adjunctive treatment for vitiligo in patients who do not respond to PUVA alone: A preliminary study
  • Başak Yalçin, Sedef Şahin, Gül Bükülmez, Ayşen Karaduman, Nilgün Atakan, Tülin Akan, Fikret Kölemen
| Article suivant Article suivant
  • Intermittent short courses of cyclosporine microemulsion for the long-term management of psoriasis: A 2-year cohort study
  • Vincent C.Y. Ho, Christopher E.M. Griffiths, John Berth-Jones, Kim A. Papp, Francisco Vanaclocha, Esteban Dauden, Anna Beard, Lohita Puvanarajan, Carle Paul

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

;

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.